| Description | Calcitonin (salmon), a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause. |
| In vivo | 经口Calcitonin salmon治疗以剂量依赖的方式减轻了干预期间的空腹和非空腹高血糖。研究结束时，按剂量计算的经口Calcitonin salmon治疗可使糖尿病高血糖降低约9 mM，并将HbA1c水平降低1.7%。此外，在口服葡萄糖耐量测试期间，经口Calcitonin salmon治疗剂量依赖地显著减少了葡萄糖波动。同时，经口Calcitonin salmon治疗在基础状态下主要维持了高胰岛素血症，并减轻了高胰高血糖素血症和高分泌的全长胰高血糖素样肽-1。最后，研究结束时，经口Calcitonin salmon治疗剂量依赖地改善了胰岛β细胞功能和β细胞区域[1]。 |
| Synonyms | 鲑降钙素, Calcitonin salmon, Salmon calcitonin |
| molecular weight | 3431.85 |
| Molecular formula | C145H240N44O48S2 |
| CAS | 47931-85-1 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 50 mg/mL (14.57 mM) |
| References | 1. Feigh M, et al. Oral salmon calcitonin attenuates hyperglycaemia and preserves pancreatic beta-cell area and function in Zucker diabetic fatty rats. Br J Pharmacol. 2012 Sep;167(1):151-63. |