| Description | Calcipotriol (MC 903) is a synthetic VitD3 analogue. Which has a high affinity for the vitamin D receptor. |
| In vitro | Calcipotriol在未刺激NHEK细胞的情况下对IL-8 mRNA表达轻微增强(0.2 nM)或无影响(2-20 nM)。当添加IL-17A和IL-22后，IL-8的mRNA表达显著增加。这种增强的IL-8 mRNA表达，通过Calcipotriol以剂量依赖的方式在2, 20, 和40 nM下被抑制[1]。将自然杀伤(NK)细胞与药物处理，调节它们NK细胞毒性受体或KIR的表达。人NK细胞预处理1,25(OH)2D3, Calcipotriol或FTY720，浓度分别为100, 10或1 ng/mL，时间为4小时。三种浓度的Calcipotriol, 1,25(OH)2D3, 和FTY720在4小时孵育后显著上调NK细胞表面的NKp30表达[2]。 |
| In vivo | 与安慰剂相比，使用Diclofenac加Calcipotriol治疗的组（p=0.018）和Diclofenac加DFMO加Calcipotriol治疗的组（p=0.002）的体重增长明显减少。生存率在各组之间均等分布。每组中的32只动物中，有一只死亡，除了Diclofenac加DFMO加Calcipotriol组外，该组动物全部存活[3]。 |
| Synonyms | MC 903, 卡泊三醇, Calcipotriene |
| molecular weight | 412.6 |
| Molecular formula | C27H40O3 |
| CAS | 112965-21-6 |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 100 mg/mL (242.37 mM) Ethanol: 50 mg/mL (121.18 mM), Sonication is recommended. |
| References | 1. Sakabe JI, et al. Calcipotriol Increases hCAP18 mRNA Expression but Inhibits Extracellular LL37 Peptide Production in IL-17/IL-22-stimulated Normal Human Epidermal Keratinocytes. Acta Derm Venereol. 2014 Sep;94(5):512-6. 2. Al-Jaderi Z, et al. Effects of vitamin D3, calcipotriol and FTY720 on the expression of surface molecules and cytolytic activities of human natural killer cells and dendritic cells. Toxins (Basel). 2013 Oct 28;5(11):1932-47. 3. Pommergaard HC, et al. Combination chemoprevention with diclofenac, calcipotriol and difluoromethylornithine inhibits development of non-melanoma skin cancer in mice. Anticancer Res. 2013 Aug;33(8):3033-9. 4. Reinhard Bredehorst, et al. Induction of Antigen-Specific Tolerance by Peripheral Phagocytosis. US 20150283231 A1. 5. Kaur A, et al. Nanoemulsion loaded gel for topical co-delivery of clobitasol propionate and calcipotriol in psoriasis. Nanomedicine. 2017 May;13(4):1473-1482. |