| Description | Calcifediol-D6 is the deuterated form of Calcifediol, which is a prehormone that is produced in the liver by hydroxylation of vitamin D3 by the enzyme cholecalciferol 25-hydroxylase. |
| In vivo | Calcifediol is converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. |
| Synonyms | 骨化二醇 D6 |
| molecular weight | 406.67 |
| Molecular formula | C27H44O2 |
| CAS | 78782-98-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Teitelbaum SL. Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease. Ann Intern Med. 1981 Mar;94(3):404-5. 2. Kleinman LM, Letteri JM, Asad SN, Ellis KJ, Cohn SH. Effects of calcifediol on calcified tissue in uremia. Arch Intern Med. 1978 May 15;138 Spec No:864-5. 3. Recker R, Schoenfeld P, Letteri J, Slatopolsky E, Goldsmith R, Brickman A. The efficacy of calcifediol in renal osteodystrophy. Arch Intern Med. 1978 May 15;138 Spec No:857-63. 4. Teitelbaum SL, Bone JM, Stein PM, Gilden JJ, Bates M, Boisseau VC, Avioli LV. Calcifediol in chronic renal insufficiency. Skeletal response. JAMA. 1976 Jan 12;235(2):164-7. |