| Description | Calanolide A, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection. |
| Synonyms | NSC 675451, NSC675451, NSC-675451 |
| molecular weight | 370.44 |
| Molecular formula | C22H26O5 |
| CAS | 142632-32-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Peng ZG, Chen HS, Wang L, Liu G. [Anti-HIV activities of HIV-1 reverse transcriptase inhibitor racemic 11-demethyl-calanolide A]. Yao Xue Xue Bao. 2008 May;43(5):456-60. Chinese. PubMed PMID: 18717330. 2. Ma T, Liu L, Xue H, Li L, Han C, Wang L, Chen Z, Liu G. Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. J Med Chem. 2008 Mar 13;51(5):1432-46. doi: 10.1021/jm701405p. PubMed PMID: 18284187. 3. Sheng L, Zhang Q, Liu Z, Liu X, Wang B, Chen H, Li Y. Determination of 10-chloromethyl-11-demethyl-12-oxo-calanolide A in rat plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetics. Biomed Chromatogr. 2014 Dec;28(12):1589-91. doi: 10.1002/bmc.3196. PubMed PMID: 24760543. 4. Liu X, Sheng L, Zhao M, Mi J, Liu Z, Li Y. In vitro glucuronidation of the primary metabolite of 10-chloromethyl-11-demethyl-12-oxo-calanolide A by human liver microsomes and its interactions with UDP-glucuronosyltransferase substrates. Drug Metab Pharmacokinet. 2015 Feb;30(1):89-96. doi: 10.1016/j.dmpk.2014.09.007. PubMed PMID: 25760535. |