| Description | Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM). |
| In vivo | GSK1265744（50 mg/kg）可防止高剂量SHIV感染恒河猴. |
| Target activity | HIV-1:3.0 nM |
| Synonyms | GSK744, GSK-1265744, 卡博特韦, S/GSK1265744 |
| molecular weight | 405.35 |
| Molecular formula | C19H17F2N3O5 |
| CAS | 1051375-10-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Yoshinaga T, et al. Antimicrob Agents Chemother. 2015, 59(1), 397-406. 2. Andrews CD, et al. Sci Transl Med. 2015, 7(270), 270-274. |