C-Type Natriuretic Peptide (1-22) acetate（human） Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	C-Type Natriuretic Peptide (CNP) (1-22), human acetate is an agonist of natriuretic peptide receptor B (NPR-B), an endothelial-derived relaxant and growth inhibitory factor. C-Type Natriuretic Peptide (CNP) (1-22), human acetate inhibits cAMP synthesis stimulated by histamine and 5-HT or directly by Forskolin.
In vitro	在表达人NPR-B的CHO细胞中, C-Type Natriuretic Peptide (CNP) (1-22), human acetate (0.01, 0.1, 1, 10, 100, 1000 nM)以浓度依赖的方式增加了cGMP的产生[2]。
In vivo	C-Type Natriuretic Peptide (CNP) (1-22), human acetate（2 nM; i.c.v.）在肽应用后24小时增加了匹克罗毒素诱发的惊厥严重性[3]。
Synonyms	C-Type Natriuretic Peptide (CNP) (1-22), human acetate(1966153-17-2 Free base)
molecular weight	2371.68
Molecular formula	C97H162F3N27O32S3
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
References	1. Buckley MG, et al. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72. 2. Morozumi N, et al. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. PLoS One. 2019 Feb 22;14(2):e0212680. 3. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24.

PeptideDB