| Description | C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. |
| In vitro | C-178 (0.01-1.25 μM) selectively reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells. It also prevents increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs) induced by cyclic di-GMP , double-stranded DNA, and LPS when used at a concentration of 0.5 μM. |
| molecular weight | 322.27 |
| Molecular formula | C17H10N2O5 |
| CAS | 329198-87-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.22 mg/mL (10 mM) |
| References | 1. Haag S M , Gulen M F , Luc R , et al. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018. |