| Description | C-176 (STING inhibitor 1) is a strong, covalent mouse STING inhibitor |
| In vitro | C-176 significantly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6. |
| In vivo | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6. |
| Synonyms | C176, STING inhibitor 1 |
| molecular weight | 358.09 |
| Molecular formula | C11H7IN2O4 |
| CAS | 314054-00-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (167.56 mM) |
| References | 1. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. 2. Duan H, et al. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015 Aug 1;23(15):4514-21. |
| Citations | 1. Liu X, Cen X, Wu R, et al.ARIH1 activates STING-mediated T-cell activation and sensitizes tumors to immune checkpoint blockade.Nature Communications.2023, 14(1): 4066. 2. Jin L, Yu B, Wang H, et al.STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.Free Radical Biology and Medicine.2023 |