| Description | Butylchlorogenate is a natural compound isolated from Lonicera japonica, Urceola rosea. |
| In vitro | Butyl chlorogenate 对α-MSH刺激的B16黑色素瘤细胞的黑色素生成抑制活性进行了评估，其中五种咖啡酰奎宁酸，即Butyl chlorogenate在100 μM浓度时展示了33-62%的黑色素含量减少，同时对细胞几乎没有或没有毒性（在100 μM时细胞存活率为89-114%）。Western blot 分析表明，Butyl chlorogenate主要以浓度依赖的方式降低了与小眼畸形相关的转录因子（MITF）、酪氨酸酶、酪氨酸相关蛋白1（TRP-1）和TRP-2的蛋白水平，表明这种化合物至少在一定程度上通过抑制MITF的表达，进而降低酪氨酸酶、TRP-1和TRP-2的表达来抑制α-MSH刺激的B16黑色素瘤细胞上的黑色素生成。 |
| molecular weight | 410.42 |
| Molecular formula | C20H26O9 |
| CAS | 132741-56-1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.11 mg/mL (10 mM) |
| References | 1. Akihisa T, et al. Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa. Chem Biodivers. 2013;10(3):313-327. 2. Kirmizibekmez H, et al. Phenolic compounds from Hypericum calycinum and their antioxidant activity. Nat Prod Commun. 2009;4(4):531-534. |