| Description | Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia. |
| In vitro | Bunaftide（0.5-2.0 mM）诱导细胞收缩和圆化，促进微绒毛样突起消失。0.4 mM Bunaftide提高了有丝分裂细胞比例，而0.8-1.0 mM Bunaftide则显著降低了这一比例，但并未导致细胞在有丝分裂的任何特定阶段累积。[1]Bunaftide（1、5、和10 mg/L）在不影响静息膜电位和动作电位幅度的情况下，引起豚鼠乳头肌制剂最大上升速率的浓度依赖性抑制。经1和5 mg/L Bunaftide处理后，动作电位持续时间（APD50、APD90）显著延长，而10 mg/L的处理则没有改变。[2] |
| Synonyms | Bunaphtide, Meregon, Bunaftine |
| molecular weight | 326.48 |
| Molecular formula | C21H30N2O |
| CAS | 32421-46-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/mL (183.78 mM) |
| References | 1. Moskalewski S, et al. Effects of bunaftine on morphology, microfilament integrity, and mitotic activity in cultured human fibroblasts and HeLa cells. Cell Tissue Res. 1984;236(1):107-15. 2. Kimura T, et al. Electrophysiological effects of bunaftine, an antiarrhythmic drug, on action potential characteristics in ventricular muscle preparations. Nihon Yakurigaku Zasshi. 1986 Jul;88(1):1-7. |