| Description | Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway. |
| Target activity | Na+, K+-ATPase α1:42.5 nM (Kd), Na+, K+-ATPase α2:45 nM (Kd), Na+, K+-ATPase α3:40 nM (Kd) |
| molecular weight | 386.52 |
| Molecular formula | C24H34O4 |
| CAS | 465-21-4 |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (129.36 mM) |
| References | 1. Chen YY, et al. Environ Toxicol. 2015 Jan;30(1):74-82. 2. Chen F, Zhu L, Hu J, et al. Bufalin attenuates triple‑negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4[J]. Oncology letters. 2020, 20(5): 1-1. |
| Citations | 1. Chen F, Zhu L, Hu J, et al. Bufalin attenuates triple‑negative breast cancer cell stemness by inhibiting the expression of SOX2/OCT4. Oncology letters. 2020, 20(5): 1-1. |