| Description | Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. Bucladesine is a phosphodiesterase inhibitor. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. |
| Synonyms | Bucladesina, DT 5621, DBC-AMP, Actosin |
| molecular weight | 469.39 |
| Molecular formula | C18H24N5O8P |
| CAS | 362-74-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: Soluble |
| References | 1. Tabrizian K, Hashemzaei M, Nasiri AA, Najafi S, Amelinia F, Sanati M, Shamshirgaran F, Fanoudi S. Interactive involvement of hippocampal cAMP/PKA and cyclooxygenase-2 signaling pathways in spatial learning in the Morris water maze. Folia Neuropathol. 2018;56(1):58-66. doi: 10.5114/fn.2018.74660. PubMed PMID: 29663741. 2. Aghsami M, Sharifzadeh M, Sepand MR, Yazdankhah M, Seyednejad SA, Pourahmad J. A cAMP analog attenuates beta-amyloid (1-42)-induced mitochondrial dysfunction and spatial learning and memory deficits. Brain Res Bull. 2018 Mar 29;140:34-42. doi: 10.1016/j.brainresbull.2018.03.016. [Epub ahead of print] PubMed PMID: 29605485. 3. Rodrigues AL, Brescia M, Koschinski A, Moreira TH, Cameron RT, Baillie G, Beirão PSL, Zaccolo M, Cruz JS. Increase in Ca(2+) current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sci. 2018 Jan 1;192:144-150. doi: 10.1016/j.lfs.2017.11.040. Epub 2017 Nov 26. PubMed PMID: 29183797. 4. Tamura K, Ishikawa G, Yoshie M, Ohneda W, Nakai A, Takeshita T, Tachikawa E. Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts. J Pharmacol Sci. 2017 Oct;135(2):89-95. doi: 10.1016/j.jphs.2017.09.032. Epub 2017 Oct 6. PubMed PMID: 29056256. |