| Description | Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs. |
| Synonyms | Btm1042, Btm-1042 |
| molecular weight | 403.97 |
| Molecular formula | C21H26ClN3OS |
| CAS | 72293-40-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Noronha-Blob L, Sturm BL, Lowe VC, Jackson KN, Kachur JF. In vitro and in vivo antimuscarinic effects of (-)cis 2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5 benzothiazepin-4-(5H)one HCl (BTM-1086) in guinea pig peripheral tissues. Life Sci. 1990;46(17):1223-31. PubMed PMID: 2338887. 2. Takayanagi I, Nakazo K, Kizawa Y. Possible mechanisms of a new type of antispasmodic drug, BTM-1042(cis-(--)-2,3-dihydro-3-(4-methyl-piperazinyl)methyl-2-phenyl-1,5-benzoth iazepin-4(5H)-one dihydrochloride). Jpn J Pharmacol. 1980 Oct;30(5):647-54. PubMed PMID: 7206371. 3. Yamamoto H, Nakamura Y, Nagasaka M, Asai H. Specificity in the pharmacological actions of optical isomers of cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one (BTM). Chem Pharm Bull (Tokyo). 1987 Aug;35(8):3419-24. PubMed PMID: 3427721. 4. Asano T, Okumura T, Hirano K, Adachi T, Sugiura M. Competitive enzyme immunoassay for anti-ulcer agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinylmethyl)-2-phenyl-1,5- benzothiazepin-4(5H)-one hydrochloride (BTM-1086). Chem Pharm Bull (Tokyo). 1986 Oct;34(10):4238-43. PubMed PMID: 3549012. |