| Description | BTK inhibitor 10 is a potent and orally active BTK inhibitor. It has the potential for rheumatoid arthritis treatment. |
| In vivo | In CIA mice, BTK inhibitor 10 (oral gavage; 30 mg/kg; 21 days; once daily) has a significant improvement in arthritis symptoms. The damage of each of the 4 paws in mice is divided into 0-4 to calculate the total score of the limbs. BTK030 (21 days; p.o.) reduces the arthritic score to 3.62 while the control group shows a value of 8.33. |
| Target activity | BTK: |
| molecular weight | 441.48 |
| Molecular formula | C25H23N5O3 |
| CAS | 2241732-30-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. HuiJun Yin, et al. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2018145525 |