| Description | BT18 is a mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 has an effect on RET receptor tyrosine kinase RetA and GDNF family receptor GFRα1 function. |
| In vitro | BT18（1-50 μM；90分钟）在MG87RET细胞系中以剂量依赖性方式激活AKT。在相同细胞系中，BT18（50 μM；1-90分钟）呈时间依赖性激活AKT和ERK1/2。BT18（5-50 μM；15分钟）在50 μM浓度下，无论是在GFP转染还是在GFRD1转染细胞中，似乎都能磷酸化RET[1]。 |
| molecular weight | 637.64 |
| Molecular formula | C30H31F4N3O6S |
| CAS | 924811-53-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 98 mg/mL (153.69 mM), Sonication is recommended. |
| References | 1. Leo Jakman, Characterization of small-molecule GDNF mimics. 2. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. |