| Description | BS-181 dihydrochloride is a selective and potent inhibitor of CDK7 with an IC50 value of 21 nM. BS-181 dihydrochloride inhibits CDK2 (IC50: 880 nM), CDK5 (IC50: 3000 nM) and CDK9 (IC50: 4200 nM), but does not block CDK1, 4 and 6. BS-181 dihydrochloride inhibits the growth of a group of cancer cells (IC50: 11.5 μM-37.3 μM) and induces apoptosis. |
| molecular weight | 453.46 |
| Molecular formula | C22H34Cl2N6 |
| CAS | 1883548-83-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |