| Description | Bruceine E is isolated from B. javanica seeds with hypoglycemia effects. Bruceine E can be used for studies about acting as an insulin secretagogue. |
| In vitro | Bruceine E 显示了显著的降低血糖浓度活性[1]。 |
| In vivo | Bruceine E（1 mg/kg b.w.）在低剂量下，不仅对非糖尿病小鼠展现出了降低血糖的效果，也对链脲佐菌素（STZ）诱导的糖尿病大鼠表现出相同的作用[3]。 |
| molecular weight | 412.43 |
| Molecular formula | C20H28O9 |
| CAS | 21586-90-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (121.23 mM) |
| References | 1. Liu JQ, et al. One new pregnane glycoside from the seeds of cultivated Brucea javanica. Arch Pharm Res. 2011 Aug;34(8):1297-300. 2. Man F, et al. HPLC-MS/MS method for bioavailability study of bruceines D & E in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 15;1063:183-188. 3. Ablat A, et al. Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats. BMC Complement Altern Med. 2017;17(1):94. Published 2017 Feb 6. |