| Description | BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. |
| In vitro | BRD7552在人类初级岛细胞和导管细胞中上调PDX1表达，并在PDX1启动子上诱导与转录激活一致的表观遗传变化。BRD7552使PDX1 mRNA水平提高2至4倍，5μM时效应最大，并增加MAFA表达。在小鼠αTC细胞中BRD7552增加PDX1表达，但在βTC细胞中则不增加。BRD7552处理PANC-1细胞可导致胰岛素mRNA表达的剂量依赖性增加。[1] |
| molecular weight | 711.63 |
| Molecular formula | C33H33N3O15 |
| CAS | 1137359-47-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 93 mg/mL (130.7 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 93 mg/mL (130.7 mM) |
| References | 1. Yuan Y, et al. Chem Biol. 2013, 20(12), 1513-1522. |