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BRD4884

CAS No.: 1404559-91-6

BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes.
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Description BRD4884 is a selective inhibitor of HDAC2 that acts by enhancing the learning and memory processes.
Target activity HDAC1:29 nM (IC50), HDAC3:1.09 μM (IC50), HDAC2:62 nM (IC50)
Synonyms BRD-4884, BRD 4884
molecular weight 314.35
Molecular formula C18H19FN2O2
CAS 1404559-91-6
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Wagner FF, Weïwer M, Steinbacher S, Schomburg A, Reinemer P, Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M, Müller P, Jefson MR, Fass DM, Haggarty SJ, Zhang YL, Holson EB. Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem. 2016 Sep 15;24(18):4008-4015. doi: 10.1016/j.bmc.2016.06.040. Epub 2016 Jun 22. PubMed PMID: 27377864. 2. Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E, Haggarty SJ, Tsai LH, Holson EB. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 1;6(1):804-815. PubMed PMID: 25642316; PubMed Central PMCID: PMC4310013.