| Description | BRCA1-IN-2 is a cell membrane-crossing BRCA1 protein-protein interaction (PPI) inhibitor with antitumor activity that acts by disrupting the interaction of BRCA1 (BRCT)2 with proteins. |
| Target activity | BRCA1:0.31 μM, BRCA1:0.3 μM (Kd) |
| molecular weight | 544.54 |
| Molecular formula | C26H33N4O7P |
| CAS | 1622262-55-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (146.91 mM), Sonication is recommended. |
| References | 1. Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156. |