| Description | BQ 484 is an endothelin (ET) receptor antagonist. |
| Synonyms | BQ485, BQ-485 |
| molecular weight | 628.76 |
| Molecular formula | C35H44N6O5 |
| CAS | 141594-26-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sakuma I, Asajima H, Fukao M, Tohse N, Tamura M, Kitabatake A. Effects of BQ-485, a selective ETA antagonist, on endothelin-mediated vasomotion in rat coronary vascular beds. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S400-3. PubMed PMID: 8587427. 2. Takasu A, Matsushima S, Takino M, Okada Y. Effect of an endothelin-1 antagonist, BQ-485, on cerebral oxygen metabolism after complete global cerebral ischemia in dogs. Resuscitation. 1997 Feb;34(1):65-9. PubMed PMID: 9051826. 3. Itoh S, Sasaki T, Ide K, Ishikawa K, Nishikibe M, Yano M. A novel endothelin ETA receptor antagonist, BQ-485, and its preventive effect on experimental cerebral vasospasm in dogs. Biochem Biophys Res Commun. 1993 Sep 15;195(2):969-75. PubMed PMID: 8373429. 4. Holló G, Kóthy P, Lakatos P, Vargha P. Endothelin-A receptor antagonist BQ-485 protects against intraocular pressure spike induced by laser trabeculoplasty in the rabbit. Ophthalmologica. 2002 Nov-Dec;216(6):459-62. PubMed PMID: 12566893. |