| Description | BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM). |
| In vitro | 1 μM BpV(Hopic) 能够在肌管条件培养基存在下，使C2C12肌母细胞的迁移能力提升约40%，而不显著影响其分化并融合成多核肌管的能力。通过1 μM BpV(Hopic) 处理的肌母细胞迁移增强与PI3K/AKT及MAPK/ERK途径的激活相关联，而使用LY294002或UO126分别抑制这两个途径，可以将C2C12的迁移能力降低到控制水平[1]。 |
| Target activity | PTEN:14 nM(Cell-free assay) |
| Synonyms | bpV (HOpic) |
| molecular weight | 347.24 |
| Molecular formula | C6H4K2NO8V |
| CAS | 722494-26-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 10 mM DMSO: Insoluble |
| References | 1. Dimchev GA, Al-Shanti N, Stewart CE.Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways.J Muscle Res Cell Motil. 2013 May;34(2):125-36. 2. Schmid A C , Byrne R D , Ramón Vilar, et al. Bisperoxovanadium compounds are potent PTEN inhibitors[J]. Febs Letters, 2004, 566(1-3):0-38. |