| Description | BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and G2/M phase. |
| Synonyms | B-P-T-Q |
| molecular weight | 308.4 |
| Molecular formula | C17H16N4S |
| CAS | 1802665-43-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Rohit Kumar H, Kumar CS, Kiran Kumar HN, Advi Rao GM. Inhibition of protein kinases by anticancer DNA intercalator, 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline. Acta Pharm Sin B. 2017 May;7(3):303-310. doi: 10.1016/j.apsb.2017.01.001. Epub 2017 Mar 7. PubMed PMID: 28540166; PubMed Central PMCID: PMC5430831. 2. RohitKumar HG, Asha KR, Raghavan SC, Advi Rao GM. DNA intercalative 4-butylaminopyrimido[4',5':4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells. Cancer Chemother Pharmacol. 2015 Jun;75(6):1121-33. doi: 10.1007/s00280-015-2735-6. Epub 2015 Mar 29. PubMed PMID: 25819915. |