| Description | BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs. |
| In vitro | BOS-318 (0.001-1 μM) 对CuFi-1细胞中由P aeruginosa外毒素A (PEA) 引发的毒性具有细胞保护作用。BOS-318在U2OS细胞中对furin的抑制活性约为PCSK5（IC50 = 25.3 nM）的13倍、PCSK7（IC50 = 45.8 nM）的24倍及PCSK6（IC50 = 209.4 nM）的110倍。BOS-318（0.3 μM, 2小时或48小时）降低了CF HBECs中ENaC介导的Na+吸收，并保护免受NE-及CF痰液溶解物激活ENaC的影响。[1] |
| molecular weight | 571.5 |
| Molecular formula | C28H32Cl2N6O3 |
| CAS | 2387633-15-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 12.5 mg/mL (21.87 mM), Sonication is recommended. |
| References | 1. Lisa E J Douglas, et al. A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol. 2022 Jun 16;29(6):947-957.e8. |