| Description | Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based linker extensively employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Synonyms | PROTAC Linker 32 |
| molecular weight | 344.45 |
| Molecular formula | C17H32N2O5 |
| CAS | 10436-21-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21. |