| Description | BN-82685 is an inhibitor of quinone-based CDC25 that is active in vitro and in vivo, which indicates the interest of the inhibition of CDC25 enzymes as an anticancer therapeutic strategy. |
| molecular weight | 265.33 |
| Molecular formula | C12H15N3O2S |
| CAS | 477603-18-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Berg MG, Wan L, Younis I, Diem MD, Soo M, Wang C, Dreyfuss G. A quantitative high-throughput in vitro splicing assay identifies inhibitors of spliceosome catalysis. Mol Cell Biol. 2012 Apr;32(7):1271-83. doi: 10.1128/MCB.05788-11. Epub 2012 Jan 17. PubMed PMID: 22252314; PubMed Central PMCID: PMC3302438. 2. Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol. 2006 Apr;18(2):185-91. Epub 2006 Feb 17. Review. PubMed PMID: 16488126. 3. Yamashita Y, Kasugai I, Sato M, Tanuma N, Sato I, Nomura M, Yamashita K, Sonoda Y, Kumabe T, Tominaga T, Katakura R, Shima H. CDC25A mRNA levels significantly correlate with Ki-67 expression in human glioma samples. J Neurooncol. 2010 Oct;100(1):43-9. doi: 10.1007/s11060-010-0147-3. Epub 2010 Mar 10. PubMed PMID: 20217459. 4. Cazales M, Boutros R, Brezak MC, Chaumeron S, Prevost G, Ducommun B. Pharmacologic inhibition of CDC25 phosphatases impairs interphase microtubule dynamics and mitotic spindle assembly. Mol Cancer Ther. 2007 Jan;6(1):318-25. PubMed PMID: 17237290. |