| Description | BMT-090605 hydrochloride is an effective and selective inhibitor of connexin-2 associated kinase 1 (AAK1) (IC50=0.6 nM). BMT-090605 hydrochloride inhibits BMP-2 induced protein kinase (BIKE) (IC50=45 nM) and cyclin G-related kinase GAK (IC50=60 nM). BMT-090605 hydrochloride shows anti-injury activity. BMT-090605 hydrochloride has research value in neuropathic pain. |
| In vitro | BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC 50 of 0.63 nM [1]. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC 50 values of 45 nM and 60 nM, respectively [1]. |
| In vivo | BMT-090605 hydrochloride(intrathecal; 0.3-3 μg/rat) causes antinociception by inhibiting AAK1 in the spinal cord [1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model) [1] Dosage: 0.3-3 μg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia. |
| molecular weight | 400.91 |
| Molecular formula | C21H25ClN4O2 |
| CAS | 2231664-45-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |