| Description | BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa; Kis: 0.2 and 0.42 nM for human and rabbit FXIa). |
| In vitro | BMS-654457 shows comparable in vitro potency against FXIa and was over 500-fold selective against coagulation-related proteases (thrombin, FXa, and FVIIa) in these species. |
| In vivo | BMS-654457 is potent in the prevention of arterial thrombosis in rabbits with limited effects on bleeding time. |
| molecular weight | 603.71 |
| Molecular formula | C36H37N5O4 |
| CAS | 1004551-41-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Wong PC, et al. In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa. J Thromb Thrombolysis. 2015 Nov;40(4):416-23. |