| Description | BMS-181101 is a novel antidepressant that has pharmacological characteristics as a serotonin reuptake inhibitor and a serotonin 5-HT receptor agonist. |
| Synonyms | BMS181101, BMS-181101 |
| molecular weight | 442.36 |
| Molecular formula | C20H26Cl2FN5O |
| CAS | 146479-45-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Newman-Tancredi A, Cussac D, Marini L, Touzard M, Millan MJ. h5-HT(1B) receptor-mediated constitutive Galphai3-protein activation in stably transfected Chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-HT. Br J Pharmacol. 2003 Mar;138(6):1077-84. PubMed PMID: 12684263; PubMed Central PMCID: PMC1573751. 2. Chang SY, Whigan D, Shyu WC, Srinivas NR. Sensitive triple-quadrupole mass spectrometric assay for the determination of BMS-181885, a 5-HT1 agonist, in human plasma following solid phase extraction. Biomed Chromatogr. 1999 Oct;13(6):425-30. PubMed PMID: 10477901. 3. Salazar DE, Fischman AJ. Central nervous system pharmacokinetics of psychiatric drugs. J Clin Pharmacol. 1999 Aug;Suppl:10S-12S. PubMed PMID: 10434241. 4. Vachharajani NN, Shyu WC, Shah VR, Barbhaiya RH. Pharmacokinetic assessment of the sites of first-pass metabolism of BMS-181101, an antidepressant agent, in rats. J Pharm Pharmacol. 1998 Mar;50(3):275-8. PubMed PMID: 9600718. |