| Description | Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor. |
| In vitro | Bisindolylmaleimide V(BIM V) blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM |
| Target activity | S6K:8 μM |
| Synonyms | 双吲哚马来酰亚胺 V, 双吲哚马来酰亚胺 |
| molecular weight | 341.36 |
| Molecular formula | C21H15N3O2 |
| CAS | 113963-68-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: soluble |
| References | 1. Marmy-Conus N , Hannan K M , Pearson R B . Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling[J]. Febs Letters, 2002, 519(1-3):0-140. 2. Lazareno S , Popham A , Birdsall N J M . Muscarinic interactions of bisindolylmaleimide analogues[J]. European Journal of Pharmacology, 1998, 360(2-3):281-284. |