| Description | Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound utilized for the synthesis of PROTACs. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| Synonyms | PROTAC Linker 19 |
| molecular weight | 148.2 |
| Molecular formula | C6H16N2O2 |
| CAS | 929-59-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 250 mg/mL (1686.91 mM), Sonication is recommended. |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |