| Description | Biotin-C1-PEG3-C3-amine (TFA) is a polyethylene glycol (PEG) based linker that serves as a crucial component in the synthesis of proteolysis targeting chimeras (PROTACs)[1]. |
| In vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| molecular weight | 545.62 |
| Molecular formula | C22H38F3N3O7S |
| CAS | 1334172-59-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |