| Description | BILB-1941 (BILB-1941ZW) is an inhibitor of HCV NS5B polymerase and can be used in studies about HCV infection. |
| Synonyms | BILB 1941ZW, BILB1941ZW, BILB-1941ZW |
| molecular weight | 562.66 |
| Molecular formula | C34H34N4O4 |
| CAS | 494856-61-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (88.86 mM) |
| References | 1. Beaulieu PL, et al. Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection. J Med Chem. 2014 Dec 11;57(23):10130-43. 2. Beaulieu PL, et al. Discovery of the first thumb pocket 1 NS5B polymerase inhibitor (BILB 1941) with demonstrated antiviral activity in patients chronically infected with genotype 1 hepatitis C virus (HCV). J Med Chem. 2012 Sep 13;55(17):7650-66. 3. Erhardt A, et al. Safety, pharmacokinetics and antiviral effect of BILB 1941, a novel hepatitis C virus RNA polymerase inhibitor, after 5 days oral treatment. Antivir Ther. 2009;14(1):23-32. |