| Description | Bictegravir Sodium (GS-9883 Sodium) is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity |
| In vitro | Bictegravir Sodium 在 MT-2 和 MT-4 细胞中强效抑制 HIV-1 复制，其半抑制浓度（EC50）分别为1.5 nM 和 2.4 nM，并且在 MT-2 和 MT-4 细胞中的选择性指数（50% 细胞毒性浓度[CC50]/EC50）分别约为6800和1500[1]。 |
| Target activity | HIV-1 integrase:7.5 nM |
| Synonyms | GS-9883 Sodium |
| molecular weight | 471.36 |
| Molecular formula | C21H17F3N3NaO5 |
| CAS | 1807988-02-8 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication and heating to 60℃ are recommended. |
| References | 1. Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097. |