| Description | Bibw 22 is a bifunctional modulator of P-glycoprotein and nucleoside transport. |
| Synonyms | Bibw22, Bibw-22 |
| molecular weight | 565.71 |
| Molecular formula | C30H43N7O4 |
| CAS | 137694-16-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chen HX, Bamberger U, Heckel A, Guo X, Cheng YC. BIBW 22, a dipyridamole analogue, acts as a bifunctional modulator on tumor cells by influencing both P-glycoprotein and nucleoside transport. Cancer Res. 1993 May 1;53(9):1974-7. PubMed PMID: 8097671. 2. Dieckmann-Schuppert A, Bamberger U, Schwarz RT. Chloroquine resistance in Plasmodium falciparum is not reversed by BIBW-22, a compound reversing the multidrug resistance phenotype in mammalian cancer cells. Biochem Pharmacol. 1993 Oct 19;46(8):1421-4. PubMed PMID: 8240391. 3. Jansen WJ, Pinedo HM, Kuiper CM, Lincke C, Bamberger U, Heckel A, Boven E. Biochemical modulation of 'classical' multidrug resistance by BIBW22BS, a potent derivative of dipyridamole. Ann Oncol. 1994 Oct;5(8):733-9. PubMed PMID: 7826906. 4. Liu Z, Lheureux F, Pouliot JF, Heckel A, Bamberger U, Georges E. BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92. PubMed PMID: 8794885. |