| Description | BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1]. |
| In vitro | BI 7446 (CDN13) (3 μM, 10 μM, 6小时) 作用后，导致THP1 STING野生型细胞中IRF3和TBK1磷酸化水平的升高[1]。 |
| In vivo | BI 7446 (CDN13) (4, 12, 36 μg, 静脉注射, 0-25 h 检测时间点) 在4T1肿瘤小鼠模型中呈现快速的血浆清除和短暂的消除半衰期[1]。同一化合物，在剂量为0.25, 1, 4 μg，通过皮下注射（每周一次）的方式，不仅显著抑制了EMT乳腺癌模型小鼠的肿瘤生长，还激发了对自体肿瘤的长期免疫记忆[1]。 |
| molecular weight | 693.52 |
| Molecular formula | C20H22FN9O10P2S2 |
| CAS | 2767011-00-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |