| Description | BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42). |
| Target activity | Aβ42:40 nM |
| molecular weight | 390.46 |
| Molecular formula | C22H23FN6 |
| CAS | 2231075-94-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble） |
| References | 1. Gerlach K, et al. Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators. Bioorg Med Chem. 2018 Jul 23;26(12):3227-3241. |