| Description | Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a corticosteroid with anti-inflammatory activity that promotes the polarization of M1 to M2 macrophages by decreasing the secretion of pro-inflammatory cytokines, and is used in the study of keloids and rheumatoid arthritis. |
| Synonyms | Vista-Methasone, NSC90616, Betamethasone 21-phosphate disodium salt, NSC-90616 |
| molecular weight | 494.42 |
| Molecular formula | C22H29FNaO8P |
| CAS | 151-73-5 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 20 mg/mL (38.73 mM), Sonication is recommended. H2O: 80 mg/mL (154.92 mM), Sonication is recommended. |
| References | 1. Wang L, et al. Determination of betamethasone disodium phosphate in the in vitro media of PLGA microspheres by high-performance liquid chromatography. J Pharm Biomed Anal. 2002;28(3-4):629-635. 2. Simon A, de Almeida Borges VR, Cabral LM, de Sousa VP. Development and validation of a discriminative dissolution test for betamethasone sodium phosphate and betamethasone dipropionate intramuscular injectable suspension. AAPS PharmSciTech. 2013 Mar;14(1):425-34. doi: 10.1208/s12249-012-9920-2. Epub 2013 Feb 1. PubMed PMID: 23371786; PubMed Central PMCID: PMC3581667. 3. Menendez MI, Phelps MA, Bertone AL. Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses. J Vet Pharmacol Ther. 2016 Feb;39(1):22-6. doi: 10.1111/jvp.12229. Epub 2015 Apr 3. PubMed PMID: 25847081. 4. Habib G, Artul S, Chernin M, Hakim G, Jabbour A. The effect of intra-articular injection of betamethasone acetate/betamethasone sodium phosphate at the knee joint on the hypothalamic-pituitary-adrenal axis: a case-controlled study. J Investig Med. 2013 Oct;61(7):1104-7. doi: 10.2310/JIM.0b013e3182a67871. PubMed PMID: 24013525. |
Betamethasone disodium phosphate
CAS No.: 151-73-5
Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt) is a corticosteroid with anti-inflammatory a
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