| Description | β-D-Glucan is a compound that targets tumor-associated macrophages with antitumor activity and modulates the immune response in necrotizing pancreatitis. |
| In vitro | 在DMSO中溶解β-D-glucan而不是在水中，会导致依赖浓度的方式抑制MCF-7细胞增殖，该作用通过BrdU掺入法确定，其IC50约为164 μg/mL。当β-D-glucan在DMSO中溶解时，对抗他莫昔芬/内分泌抵抗的LCC9和LY2细胞增殖的抑制作用的IC50值分别为4.6 μg/mL和24.2 μg/mL。[3] |
| molecular weight | N/A |
| CAS | 9041-22-9 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | NaOH: 10 mg/mL, when pH is adjusted to 12 with 1 M NaOH. Sonication is recommended |
| References | 1. Su Y, et al. pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery. Carbohydr Polym. 2020 Oct 15;246:116621. 2. Gani A, et al. β-d-glucan as an enteric delivery vehicle for probiotics. Int J Biol Macromol. 2018 Jan;106:864-869. 3. Jafaar ZM, et al. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014 Apr;44(4):1365-75. |