| Description | β-CGRP, human acetate is one of calcitonin peptides and acts via the complex of receptor-activity-modifying protein (RAMP) and calcitonin-receptor-like receptor (CRLR) (IC50s: 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells). |
| In vitro | β-CGRP, human 通过与 CRLR 和 RAMP 的复合体发挥作用，在表达 CRLR 和 RAMP1 的 SK-N-MC 和 Swiss 3T3 细胞中的 IC50 均为 1 nM，而在表达 CRLR 和 RAMP2 的 HEK293T 和 NG108-15 细胞中分别为 300 nM 和 130 nM [1]。CGRP 是一种强效的血管舒张剂，同时还具有促进和抗炎活性 [2]。 |
| Target activity | CRLR/RAMP1:1 nM , CRLR/RAMP2:300 nM |
| Synonyms | β-CGRP, human acetate (101462-82-2 free), CGRP-II (Human) (acetate), Human β-CGRP acetate |
| molecular weight | 3853.46 |
| Molecular formula | C164H271N51O50S3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. McLatchie LM, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. 2. Russell FA, et al. Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 2014 Oct;94(4):1099-142. |