| Description | β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2]. |
| In vitro | β-catenin-IN-6（化合物9）（24小时）对LoVo和HT29细胞线具有显著的抑制效果，其半抑制浓度（IC50）分别为1.4 μM和1.37 μM。研究表明，β-catenin-IN-6能有效抑制多种人类结直肠癌细胞系的生长[1]。 |
| In vivo | β-catenin-IN-6 (compound 9)的生物利用度不佳[1]。 给予小鼠β-catenin-IN-6 (18.75 mg/kg；腹腔注射；每天一次，连续7天)能显著缩小肿瘤体积，而不影响其体重[1]。 同时，β-catenin-IN-6 (compound 13) (150 mg/kg；腹腔注射；每周一次)在β-catenin/RK3E小鼠模型上的异植肿瘤生长上表现出抑制效果[2]。 |
| molecular weight | 418.88 |
| Molecular formula | C22H19ClN6O |
| CAS | 1039731-99-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |