| Description | Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic agent and increases intra-arterial pressure due to the increased peripheral vascular resistance. |
| In vivo | Benzquinamide (0.5至5 mg/kg; i.v.) 引起心动过速、血中去甲肾上腺素水平升高、频繁的心室性心律失常以及短暂的低血压。在给予Benzquinamide之前，使用hexamethonium进行神经节阻断可以预防心动过速和去甲肾上腺素水平的改变，但会延长低血压的时间。在隔离的肠系膜动脉准备中，Benzquinamide 干扰了由氯化钾、去甲肾上腺素和前列腺素F2α[3]生成的收缩力。 |
| Synonyms | 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride |
| molecular weight | 440.96 |
| Molecular formula | C22H33ClN2O5 |
| CAS | 113-69-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (124.16 mM) |
| References | 1. BURSTEIN CL. Benzquinamide:cardiovascular stimulant useful during general anesthesia. Anesth Analg. 1963 Jul-Aug;42:429-34. 2. Kingston RS, et al. Cardiovascular effects of benzquinamide in man. Acta Anaesthesiol Scand. 1975;19(3):187-92. 3. Smith DJ, et al. Cardiovascular effects of benzquinamide. Anesth Analg. 1979 May-Jun;58(3):189-94. |