| Description | Benperidol (Anquil) is a butanone analog with antipsychotic and stabilizing properties, and has been shown to be effective in blocking D2 receptors.Benperidol can be used in positron emission tomography (PET) scanning to measure D(2) dopamine receptor binding in vivo.Benperidol has been shown to be effective in blocking D2 receptors in vivo.Benperidol has been shown to be effective in blocking D2 receptors in vivo. |
| Synonyms | R4584, R-4584, Anquil, McN-JR-4584, R 4584 |
| molecular weight | 381.44 |
| Molecular formula | C22H24FN3O2 |
| CAS | 2062-84-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (235.9 mM), Sonication is recommended. |
| References | 1. Süss S, et al. Determination of benperidol and its reduced metabolite in human plasma by high-performance liquid chromatography and electrochemical detection. J Chromatogr. 1991;565(1-2):363-373. 2. Leucht S, et al. Benperidol for schizophrenia. Cochrane Database Syst Rev. 2005;2005(2):CD003083. 3. Schmidt A, et al. Influence of intravenous administration of the antipsychotic drug benperidol on the QT interval. Einfluss der intravenösen Applikation des Antipsychotikums Benperidol auf das QT-Intervall. Neuropsychiatr. 2017;31(4):172-175. 4. Seiler W, et al. Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application. Psychopharmacology (Berl). 1994;116(4):457-463. |