| Description | BD-AcAc 2 (Ketone Ester) is a ketone monoester and can be used as a source of oral nutritional ketones. BD-AcAc 2 can elevate plasma levels of acetoacetate and β-hydroxybutyrate, blood Na+, blood glucose levels and blood creatinine levels after oral administration in mice. BD-AcAc 2 can partly prevent muscle weakness in septic mice. BD-AcAc 2 exhibits potential to improve endurance and exercise performance in animal body. BD-AcAc 2 can also be used to research diabetes or Parkinson’s disease. |
| In vivo | BD-AcAc(2)能延迟在高压氧环境下(HBO(2))呼吸的大鼠CNS-OT抽搐。成年雄性大鼠(60只)植入无线电遥测装置以记录脑电图(EEG)。术后一周，大鼠口服单剂BD-AcAc(2)、1,3-丁二醇(BD)或水，30分钟后置于高压氧舱内压力调至5大气绝对值(ATA) [1]。从症状未发作的年龄开始，两组3xTgAD雄性小鼠分别喂食含生理对映体前体的酮体(KET)饮食或等热量的碳水化合物饮食。行为测试（测试起始于饮食后4个和7个月）结果显示，KET饲养的小鼠在两种不同的测试中明显减少了焦虑。KET饮食的3xTgAD小鼠还在学习记忆测试中表现出显著。免疫组化分析揭示，KET饲养的小鼠在海马的下回、CA1区域、CA3区域和杏仁体中Aβ沉积减少[2]。 |
| Synonyms | Ketone Ester |
| molecular weight | 176.21 |
| Molecular formula | C8H16O4 |
| CAS | 1208313-97-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 96 mg/mL (544.80 mM), Sonication is recommended. H2O: 30 mg/mL (170.25 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. D'Agostino DP, et al. Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats. Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R829-36. 2. Kashiwaya Y, et al. A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging. 2013 Jun;34(6):1530-9. |