| Description | BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia. |
| In vitro | BCAT-IN-2 能抑制分化的原代人脂肪细胞中的 BCATm，pIC50 为 6.5 [1]。 |
| In vivo | BCAT-IN-2（5 mg/kg，po；1 mg/kg，iv）在小鼠体内显示出良好的药代动力学参数[1]。 |
| Target activity | BCAT (rat, mitochondrial):7.39 (pIC50), BCAT (rat, cytosolic):6.6 (pIC50) |
| molecular weight | 377.776 |
| Molecular formula | C17H14ClF2N5O |
| CAS | 1800024-45-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30 mg/mL (79.41 mM), Sonification is recommended. |
| References | 1. Bertrand SM, et al. The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. J Med Chem. 2015 Sep 24;58(18):7140-63. |