| Description | BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-CL-Yne inhibits PAD1-4 with Kinact/KI values of 6,400, 3,600, 10,800, and 4,900 M-1min-1, respectively. It has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. |
| molecular weight | 483.99 |
| Molecular formula | C28H26ClN5O |
| CAS | 2219324-71-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 20 mg/mL DMSO: 5 mg/mL DMF:PBS (pH 7.2) (1:5): 0.16 mg/mL |