| Description | Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. |
| In vitro | Bay K 8644 increases resting tension in segments of mesenteric arteries isolated from young and old rats as an agonist of L-type Ca2+ channel[2] |
| In vivo | Bay K 8644 induces small contractions in aortae from Wistar-Kyoto(WKY) rats of 5-week-, 3-month-, 1-year-, 1.5-year-old, which are unaltered with age.[3] |
| Target activity | Ca2+ channel, L-type:17.3nM(EC50) |
| Synonyms | (±)-BAY-K-8644, SQ 28,873 |
| molecular weight | 356.3 |
| Molecular formula | C16H15F3N2O4 |
| CAS | 71145-03-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 35.6 mg/mL (100 mM) |
| References | 1. A J Gonzales,et al. Br J Pharmacol. 1989, 96(2):333-340 2. Sulayma A. Albarwani,et al. Front Physiol. 2016, 7:171. 3. Hernández MC, et al. J Auton Pharmacol. 1995 Aug;15(4):257-69. |