| Description | BAY-7598 is a potent, selective, and orally bioavailable MMP12 inhibitor (IC50s: 0.085, 0.67, and 1.1 nM for human/murine/rat MMP12). |
| In vitro | BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM). BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM). BAY-7598 inhibits rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM). |
| In vivo | BAY-7598 has moderate terminal elimination half-life (t1/2=4.1 h and 4.6 h for mouse (5.0 mg/kg, p.o.), mouse (0.3 mg/kg, iv), respectively). |
| Target activity | MMP12 (murine):0.67 nM , MMP12 (human):0.085 nM , MMP12 (rat):1.1 nM |
| molecular weight | 505.56 |
| Molecular formula | C28H31N3O6 |
| CAS | 1816257-74-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chemical Probe BAY-7598 MMP12 Inhibitor. |