| Description | BAY 73-1449 is a selective and potent antagonist of the prostacyclin receptor(IC50<0.1 nM). |
| In vivo | 在雄性Wistar大鼠中，BAY 73-1449（0.1-1 mg/kg；静脉注射）显著减少脾脏分流血管的流出，而不影响肠系膜的流入[1]。BAY 73-1449（1-5 mg/kg；皮下注射）对大鼠的门脉压力和门体循环分流的程度没有影响[1]。 |
| Target activity | Prostacyclin receptor:<0.1 nM |
| Synonyms | BAY-73-1449, BAY73-1449 |
| molecular weight | 425.48 |
| Molecular formula | C26H23N3O3 |
| CAS | 693790-96-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/ml (129.27 mM), Sonication is recommended. |
| References | 1. Bexis S, et, al. Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6. |