| Description | Bapotulimab (BAY-1905254) is a fully human IgG2 antibody that targets the immunoglobulin-like domain-containing receptor 2 (ILDR2), exhibiting antitumor and immunosuppressive effects [1]. |
| In vitro | Bapotulimab通过阻断ILDR2的免疫抑制功能，激活T细胞。由于ILDR2在人类和小鼠之间的细胞外结构域具有98%的序列一致性，Bapotulimab表现出小鼠/人交叉活性 [1]。在体外实验中，Bapotulimab (BAY-1905254；浓度为5、25、100或500 ng/mL)能够促进T细胞的激活并加强抗原特异性T细胞的增殖 [1]。 |
| In vivo | Bapotulimab（BAY-1905254；10 mg/kg；腹腔注射；第1天与第4天）可显著促进抗原特异性T细胞的增殖及细胞毒性作用[1]。 |
| Synonyms | BAY-1905254 |
| molecular weight | N/A |
| CAS | 2359413-58-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |